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Carisoprodol (commonly known as Soma), a muscle relaxant, is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.

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CARISOPRODOL DRUG INFO


Why is this medication prescribed?

Carisoprodol, a muscle relaxant, is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Carisoprodol comes as a tablet to take by mouth. It usually is taken three times daily and at bedtime. It may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take carisoprodol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What special precautions should I follow?

Before taking carisoprodol,

  • tell your doctor and pharmacist if you are allergic to carisoprodol, meprobamate (Equanil, Meprospan, Miltown, Neuramate), or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially medications for allergies, coughs, or colds; muscle relaxants; sedatives; sleeping pills; tranquilizers; and vitamins.
  • tell your doctor if you have or have ever had kidney or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking carisoprodol, call your doctor.
  • you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how carisoprodol affects you.
  • remember that alcohol can add to the drowsiness caused by this drug.
What special dietary instructions should I follow?

Carisoprodol may cause an upset stomach. Take carisoprodol with food or milk.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Although side effects from carisoprodol are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

  • drowsiness
  • dizziness
  • clumsiness
  • headache
  • fast heart rate
  • upset stomach
  • vomiting
  • skin rash

If you experience any of the following symptoms, call your doctor immediately:

  • difficulty breathing
  • fever
  • weakness
  • burning in the eyes
What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from moisture and heat (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

Carisoprodol

From Wikipedia, the free encyclopedia

Carisoprodol
Systematic (IUPAC) name
[2-methyl-2-(1-methylethylcarbamoyloxymethyl) pentyl]aminomethanoate
Identifiers
CAS number 78-44-4
ATC code M03BA02
PubChem 2576
DrugBank APRD00417
Chemical data
Formula C12H24N2O4 
Mol. mass 260.33 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 60%
Metabolism Hepatic (CYP2C19-mediated)
Half life 8 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?

Legal status

-only(US) Scheduled in some U.S. states

Routes Oral

Carisoprodol is a skeletal muscle relaxant whose active metabolite is meprobamate. Although several case reports have shown that carisoprodol has abuse potential[citation needed], it continues to be widely prescribed (except in the United Kingdom where use of benzodiazepines is preferred). Carisoprodol is a colorless, crystalline powder, having a mild, characteristic odor and a bitter taste. It is slightly soluble in water and freely soluble in alcohol, chloroform and acetone. Its solubility is practically independent of pH. It is marketed in the United States under the brand name Soma, and in the United Kingdom and other countries under the brand name Carisoma.

Contents

[hide]

History

Meprobamate and other muscle relaxing drugs often were subjects of misuse and abuse in the 1950s and 1960s.[1][2] Overdose cases were reported as early as 1957 and have been reported on several occasions since then.[3][4][5][6][7][8][9]

On June 1, 1959 several American pharmacologists convened at Wayne State University in Detroit, Michigan to discuss a new drug. The drug, originally thought to have antiseptic properties, was found to have central muscle relaxing properties.[10] It had been developed by Dr. Frank M. Berger at Wallace laboratories and had been named carisoprodol (trade name Soma).

Carisoprodol was developed on the basis of meprobamate, in the hope that it would have better muscle relaxing properties, less potential for abuse, and less risk of overdose than meprobamate.[11] The substitution of one hydrogen atom with an isopropyl group on one of the carbamyl nitrogens was intended to yield a molecule with new pharmacological properties.

Chemistry

It is a carbamic acid ester. Carisoprodol is a racemic mixture of two stereoisomers.

Effects

Side effects

These are somewhat rare when used at normal doses.

Pharmacokinetics

Carisoprodol has a rapid, 30 minute onset of action, with the aforementioned effects lasting for approximately 2–6 hours. It is metabolized in the liver via the cytochrome P450 oxidase isozyme CYP2C19, excreted by the kidneys and has an approximate 8 hour half-life. A considerable proportion of carisoprodol is metabolized to meprobamate, which is a known drug of abuse and dependence; this could account for the abuse potential of carisoprodol.

Notes

  1. ^ Kamin I, Shaskan D. (1959). "Death due to massive overdose of meprobamate". Am J Psychiatry 115 (12): 1123-1124. 
  2. ^ Hollister LE (1983). "The pre-benzodiazepine era". J Psychoactive Drugs 15 (1-2): 9-13. 
  3. ^ Gaillard Y, Billault F, Pepin G (1997). "Meprobamate overdosage: a continuing problem. Sensitive GC-MS quantitation after solid phase extraction in 19 fatal cases". Forensic Sci.Int 86 (3): 173-180. 
  4. ^ Allen MD, Greenblatt DJ, Noel BJ (1977). "Meprobamate overdosage: a continuing problem". Clin Toxicol 11 (5): 501-515. 
  5. ^ Kintz P, Tracqui A, Mangin P, Lugnier AA (1988). "Fatal meprobamate self-poisoning". Am J Forensic Med Pathol 9 (2): 139-140. 
  6. ^ Eeckhout E, Huyghens L, Loef B, Maes V, Sennesael J (1988). "Meprobamate poisoning, hypotension and the Swan-Ganz catheter". Intensive Care Med 14 (4): 437-438. 
  7. ^ Lhoste F, Lemaire F, Rapin M (1977). "Treatment of hypotension in meprobamate poisoning". N Engl J Med 296 (17): 1004. 
  8. ^ Bedson H (1959). "Coma due to meprobamate intoxication. Report of a case confirmed by chemical analysis". Lancet 273 (1): 288-290. 
  9. ^ Blumberg A, Rosett H, Dobrow A (1959). "Severe hypotension reactions following meprobamate overdosage". Ann Intern Med 51: 607-612. 
  10. ^ Miller JG, ed. The pharmacology and clinical usefulness of carisoprodol. Detroit:Wayne State University; 1959.
  11. ^ Berger F, Kletzkin M, Ludwig B, Margolin S. The history, chemistry, and pharmacology of carisoprodol. Annals of the New York Academy of Sciences. 1959;86:90-107

References

  • APhA Drug Information Handbook

External links